How the "vaccinated" produce variants, why they suffer repeat infections with SARS-CoV-2, and progress to COVID disease more often than the "unvaccinated".
A layman's guide.
I read Dr Paul Alexander, Geert Vanden Bossche, Bad Cattitude and Dr Robert Malone daily (sometimes ten times a day thanks to Paul!). They often write about the virology and immunology explaining how and why the mRNA injections, aka “vaccines”, can be responsible for unnatural selection of variants, repeat infections and more frequent progression to disease for the vaccinated. But what does this all mean?
I’m going to test my own understanding and attempt to explain it in lay terms for those of us who can’t always make head nor tail of the experts. Inevitably, it won’t be complete and perhaps not entirely accurate but I’m just trying to convey the gist of it as simply as I can.
Virology is the scientific study of biological viruses. It is a subfield of microbiology that focuses on their detection, structure, classification and evolution, their methods of infection and exploitation of host cells for reproduction, their interaction with host organism physiology and immunity, and the diseases they cause.1
SARS-CoV-2 is the name given to the virus that causes the disease COVID-19. Different parts of the virus are called epitopes. One significant epitope of SARS-CoV-2 is the spike protein - a hook on the outside of the envelope protein that the virus uses to latch onto host cells, and penetrate them so it can reproduce itself using the cell machinery (Figure 1).
SARS-CoV-2 has affinity with part of the human cell called an ACE2 receptor. It uses this to unlock the cell like a key to a door (Figure 2).
Immunology is a branch of medicine and biology that covers the medical study of immune systems. It studies the relationship between the body systems, pathogens, and immunity.2
The human immune system is incredibly complex with many moving parts but for the sake of simplicity, I’m just going to focus on what is known as the “adaptive” system because this ties in with the COVID vaccine. It is where your body mounts a specific defence against an invading pathogen like a virus. It then remembers that response for the next time it encounters that pathogen because the process takes a few days the first time around.
The body produces lots of “antibodies” that attempt to bind to the various epitopes of the virus. The ones that are best adapted can block the virus’s ability to infect a cell. This is called “neutralisation”.
When antibodies bind to the virus, they signal to other parts of the immune system to help them deal with it, like white blood cells (“phagocytes”) that literally eat the virus and kill it (Figure 4).
However, if the virus is not neutralised, once inside the phagocyte, it can actually use it to reproduce like other host cells. This is known as antibody dependent enhancement or ADE for short because the antibody has actually helped the virus to infect.
It is posited that the “leaky” COVID vaccine, i.e. one that does not produce neutralising antibodies, is responsible for enhanced infection and disease in the vaccinated but this is not conclusively supported with empirical hospitalisation and death data.
Viruses mutate all the time, resulting in different “variants”. Usually, the variants that succeed, i.e. become dominant, are the ones that are least harmful and most transmissible because they do not force the host to retreat from contact with others.
However, if the body’s adaptive immunity memory is fixated on a narrow antibody response to the different variants, the antibodies can facilitate the selection of variants that would ordinarily not be selected (Figure 5).
It is posited that this is happening with the COVID vaccine which produces more and more of the antibodies to the spike protein of the original Wuhan variant that stopped circulating a long time ago.
This is especially the case if there is “infectious pressure”, which simply means a lot of viral activity and is known as original antigenic sin or OAS for short.
It is actually not uncommon at the individual level and explains why we get colds and flu throughout our lifetimes (and also why there has never been an effective cold or flu vaccine!) but healthy individuals cope by relying on the other part of their immune system - the innate system - which is a more general line of defence.
However, the older you get, the weaker your innate immunity becomes, partly because you have developed your adaptive system.
If this happens in a lot of people at the same time with the same fixation, i.e. at the population level, we have “herd-level antigenic fixation” (see below).
What this means is, by overtraining the adaptive system with the same irrelevant, non-neutralising antibodies to the original Wuhan spike, this immune response is dominating all the others so the vaccinated will keep on getting infected and the virus will not go away at the population level.
Inevitably, this has repercussions on the unvaccinated too as they are having to deal with so many variants in quick succession which can also out-compete their own immune systems if they are not fit.
For useful reference material, I can recommend Paul Alexander’s article in Brownstone - 53 Efficacy Studies that Rebuke Vaccine Mandates which expounds the evidence on vaccines not reducing injection and disease, even if you believe they reduce severe illness and death for a short period.
And I thoroughly recommend this article from El Gato on herd-level antigenic sin:
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